p21-Activated Kinase 4 Promotes Intimal Hyperplasia and Vascular Smooth Muscle Cells Proliferation during Superficial Femoral Artery Restenosis after AngioplastyReportar como inadecuado




p21-Activated Kinase 4 Promotes Intimal Hyperplasia and Vascular Smooth Muscle Cells Proliferation during Superficial Femoral Artery Restenosis after Angioplasty - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BioMed Research International - Volume 2017 2017, Article ID 5296516, 8 pages - https:-doi.org-10.1155-2017-5296516

Research ArticleDepartment of Vascular Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China

Correspondence should be addressed to Junmin Bao and Zaiping Jing

Received 28 December 2016; Accepted 3 May 2017; Published 19 June 2017

Academic Editor: Rei Shibata

Copyright © 2017 Liangxi Yuan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of this study is to explore the function of p21-activated kinase 4 PAK4 in intimal hyperplasia IH and vascular smooth muscle cells VSMCs proliferation. We choose vascular samples from patients undergoing angioplasty in superficial femoral artery SFA as the experimental group and vascular samples from donors without clinical SFA restenosis as the control group, respectively. We draw from the results that both levels of mRNA and protein of PAK4 in the experimental group increased dramatically compared with the control group. IH arose from angioplasty of SFA. Moreover, overexpression of PAK4 dramatically contributed to cell proliferation of VSMCs and promoted cell cycle progression from G0-G1 phase % versus %, into S phase % versus %, . Besides, PAK4 downregulated the level of p21 and enhanced the activity of Akt as well. And we conclude that PAK4 acts as a regulator of cell cycle progression of VSMC by mediating Akt signaling and controlling p21 levels, which further modulate IH and VSMCs’ proliferation.





Autor: Liangxi Yuan, Xianli Duan, Jian Dong, Qingsheng Lu, Jian Zhou, Zhiqing Zhao, Junmin Bao, and Zaiping Jing

Fuente: https://www.hindawi.com/



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