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BMC Cardiovascular Disorders

, 14:101

Epidemiology

Abstract

BackgroundAlthough many studies have examined the relationship between uric acid UA and coronary artery disease CAD, whether UA is an independent risk factor contributing to progression of CAD is still controversial. Whether UA plays a different role in different sexes is also unclear.

MethodsA total of 1116 individuals with suspected CAD were stratified into four groups according to their serum UA quartiles in total men and women combined, in men, and in women. The association of UA with coronary atherosclerosis was assessed by univariable and multivariable logistic regression.

ResultsIn total and in women, the prevalence of any plaques and significant-severe stenosis was significantly increased with an increase in quartiles of UA all P < 0.05. The proportion of triple-vessel disease and left main artery lesion was highest in the fourth quartile both p < 0.05. Increasing quartiles of UA were significantly associated with a coronary artery calcium score CACS >10 all P < 0.01. As UA levels increased in women, the incidence of double-vessel lesions p = 0.017 and the proportion of mixed plaques p = 0.022 were significantly increased. The proportion of a CACS of 0 in total, in men and women was highest in the first quartile all P < 0.01. UA was the strongest predictor of significant stenosis, multivessel disease, and mixed plaques in women all p < 0.05. UA was the only risk factor for mixed plaques in total P = 0.046.

ConclusionThe level of UA was significantly associated with coronary atherosclerosis in women, but not men.

KeywordsUric acid Coronary atherosclerosis Coronary computed tomography angiography Gender Calcium score AbbreviationsUAUric acid

CADCoronary artery disease

CCTACoronary computed tomography angiography

CACSCalcium score

BMIBody mass index

TCTotal cholesterol

TGTriglyceride

HDL-CHigh-density lipoprotein cholesterol

LDL-CLow-density lipoprotein cholesterol

CAGCoronary artery angiography.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2261-14-101 contains supplementary material, which is available to authorized users.

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Autor: Yujiao Sun - Xin Yu - Ying Zhi - Song Geng - Hua Li - Ting Liu - Ke Xu - Ling Chen - Chunwei Wu - Guoxian Qi

Fuente: https://link.springer.com/article/10.1186/1471-2261-14-101







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