Vitamin D levels are low in adult patients with sickle cell disease in Jamaica and West AfricaReportar como inadecuado




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BMC Hematology

, 14:12

First Online: 16 August 2014Received: 12 November 2013Accepted: 12 August 2014

Abstract

BackgroundPatients with sickle cell disease in the USA have been noted to have lower levels of vitamin D – measured as 25-hydroxyvitamin D 25OHD – compared to controls. Average serum 25OHD levels are also substantially lower in African Americans than whites, while population distributions of 25OHD among Jamaicans of African descent and West Africans are the same as among USA whites. The purpose of this study was to examine whether adult patients with sickle cell disease living in tropical regions had reduced 25OHD relative to the general population.

MethodsWe analyzed serum 25OHD in stored samples collected from studies in Jamaica and West Africa of adult patients with sickle cell disease and adult population controls.

ResultsIn samples of 20 Jamaicans and 50 West Africans with sickle cell disease mean values of 25OHD were 37% and 39% lower than controls, respectively. Metabolic abnormalities in the absorption and conversion pathways are possible causes for the consistent relative deficiency of 25OHD in sickle cell disease.

ConclusionsLow 25OHD levels in tropical Africa where the burden of sickle cell disease is highest, deserve further investigation, and a randomized trial is warranted to address efficacy of supplementation.

KeywordsSickle cell disease Sickle cell anemia Vitamin D 25-hydroxyvitamin D Adult patients Tropical Africa Jamaica West Africa Abbreviations25OHD25-hydroxyvitamin D

BMIBody mass index

SCDSickle cell disease

SDStandard deviation

SRMStandard reference material

USAUnited States of America

UVBUltraviolet B.

Electronic supplementary materialThe online version of this article doi:10.1186-2052-1839-14-12 contains supplementary material, which is available to authorized users.

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Autor: Bamidele O Tayo - Titilola S Akingbola - Babatunde L Salako - Colin A McKenzie - Marvin Reid - Jennifer Layden - Ifeyinw

Fuente: https://link.springer.com/article/10.1186/2052-1839-14-12







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