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Osteoporosis International

, Volume 26, Issue 3, pp 1045–1052

First Online: 19 November 2014Received: 22 July 2014Accepted: 23 October 2014

Abstract

SummaryPostmenopausal osteoporosis is the most common metabolic bone disease with important genetic factors. We evaluated the frequency of polymorphism 283G-A of the vitamin D3VDR gene receptor. The study included 800 women at the postmenopausal 505 and reproductive 295 age. Statistically significant changes, depending on the genotype, were shown.

IntroductionPostmenopausal osteoporosis is the most common metabolic bone disease of strong genetic origin with population variability determined by the interaction of genetic and environmental factors. Recognition of different genetic variants underlying development of osteoporosis would make it possible to administer individual symptomatic treatment as well as early prophylactics of osteoporosis.

MethodsThe aim of the study was to evaluate the frequency of polymorphism 283G-A of the vitamin D3VDR gene receptor and assessment of its relations with the clinical parameters of osseous turnover and degree of postmenopausal osteoporosis.

The study included 800 women at the postmenopausal 505 and reproductive 295 age throughout the Wielkopolska region in Poland. The postmenopausal group included women with osteoporosis and osteopenia and the healthy ones. Women at the reproductive age were healthy. Frequency of the tested gene polymorphism was evaluated in the group where bone mineral density BMD was marked and in the control group.

ResultsThe obtained test results pointed to correlation of polymorphism VDR 283G-A with the BMD scores for the lumbar vertebrae in women with osteopenia and osteoporosis, therefore the ones at risk of fractures. Vitamin D receptor VDR polymorphism correlated with reduced BMD values.

ConclusionsPolymorphism 283G-A of the vitamin D3 receptor gene has been proved to be the genetic factor of postmenopausal osteoporosis. The polymorphism mentioned above has been proved to be a factor of mineral bone density changes of women.

KeywordsAge Females Osteoporosis Polymorphism VDR gene  Download fulltext PDF



Autor: D. Boroń - A. Kamiński - D. Kotrych - A. Bogacz - I. Uzar - P. M. Mrozikiewicz - B. Czerny

Fuente: https://link.springer.com/



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