Differential association between metabolic syndrome and coronary artery disease evaluated with cardiac computed tomography according to the presence of diabetes in a symptomatic Korean populationReportar como inadecuado




Differential association between metabolic syndrome and coronary artery disease evaluated with cardiac computed tomography according to the presence of diabetes in a symptomatic Korean population - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Cardiovascular Disorders

, 14:105

Coronary artery disease

Abstract

BackgroundMetabolic syndrome MetS is associated with increased risks of diabetes and coronary artery disease CAD. Despite the controversial inclusion of established diabetes in MetS, the association between MetS and CAD according to diabetes status has not been elucidated in the Asian population.

MethodsWe evaluated the association between MetS and CAD using the parameters including any plaque, obstructive plaque, and coronary artery calcium score CACS >100 according to diabetes status in 2,869 symptomatic Korean subjects who underwent cardiac computed tomographic angiography.

ResultsThe prevalence of MetS was significantly higher in the diabetic subjects than in the non-diabetic subjects 69% vs. 34%, P <0.001. The incidence of any plaque 64% vs. 43%, P <0.001, obstructive plaque 26% vs. 13%, P = 0.006, and CACS >100 23% vs. 12%, P = 0.012 was significantly higher in diabetic subjects than in non-diabetic subjects. Among the MetS components, decreased high-density lipoprotein level was significantly associated with any plaque odds ratio OR 1.35, obstructive plaque OR 1.55, and CACS >100 OR 1.57 in the non-diabetic subjects P <0.01, respectively. However, none of the MetS components were associated with all the parameters in the diabetic subjects. Multivariate regression analysis revealed that MetS and the number of MetS components MetSN were independently associated with any plaque MetS: OR 1.55, P <0.001; MetSN: OR 1.22, P <0.001, obstructive plaque MetS: OR 1.52, P = 0.003; MetSN: OR 1.25, P <0.001, and CACS >100 MetS: OR 1.46, P = 0.015; MetSN: OR 1.21, P = 0.004 only in the non-diabetic subjects, respectively.

ConclusionsMetS was independently associated with the presence and severity of CAD only in the non-diabetic subjects among the symptomatic Korean population.

KeywordsMetabolic syndrome Diabetes Coronary artery disease Coronary computed tomographic angiography AbbreviationsBMIBody mass index BMI

CACSCoronary artery calcium score

CADCoronary artery disease

cCTACoronary computed tomographic angiography

CHDCoronary heart disease

CIConfidence intervals CI

CMPCalcified or mixed plaque

CVCardiovascular

GFRGlomerular filtration rate

HDLHigh-density lipoprotein

LDLLow-density lipoprotein

MetSMetabolic syndrome

MetSNNumber of MetS components

MDCTMultidetector computed tomography

NCPNon-calcified plaque

OROdds ratios

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2261-14-105 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Autor: Ki-Bum Won - Hyuk-Jae Chang - Jimin Sung - Sanghoon Shin - In-Jeong Cho - Chi-Young Shim - Geu-Ru Hong - Young Jin Kim -

Fuente: https://link.springer.com/article/10.1186/1471-2261-14-105



DESCARGAR PDF




Documentos relacionados