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Depression Research and TreatmentVolume 2011 2011, Article ID 529638, 6 pages

Research Article

Department of Psychological Medicine, University of Otago Christchurch, P.O. Box 4345, Christchurch Mail Centre, Christchurch 8140, New Zealand

Department of Pathology, University of Otago Christchurch, Christchurch 8140, New Zealand

Department of Public Health and General Practice, University of Otago, Christchurch, Christchurch 8140, New Zealand

Received 15 February 2011; Accepted 26 April 2011

Academic Editor: Fossati Andrea

Copyright © 2011 James A. Harley et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Personality traits are potential endophenotypes for genetic studies of psychiatric disorders. One personality theory which demonstrates strong heritability is Cloninger-s psychobiological model measured using the temperament and character inventory TCI. 277 individuals who completed the TCI questionnaire as part of the South Island Bipolar Study were also interviewed to assess for lifetime psychiatric diagnoses. Four groups were compared, bipolar disorder BP, type 1 and 2, MDD major depressive disorder, and nonaffected relatives of a proband with BP. With correction for mood state, total harm avoidance HA was higher than unaffected in both MDD and BP groups, but the mood disorder groups did not differ from each other. However, BP1 individuals had higher self-transcendence ST than those with MDD and unaffected relatives. HA may reflect a trait marker of mood disorders whereas high ST may be specific to BP. As ST is heritable, genes that affect ST may be of relevance for vulnerability to BP.





Autor: James A. Harley, J. Elisabeth Wells, Christopher M. A. Frampton, and Peter R. Joyce

Fuente: https://www.hindawi.com/



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