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Cardiovascular Diabetology

, 13:125

First Online: 21 August 2014Received: 21 May 2014Accepted: 07 August 2014

Abstract

BackgroundAbnormal ventricular repolarization is a predictor of cardiovascular mortality. In this study, we tested the hypothesis that glycemic control reverses abnormal ventricular repolarization in patients with type 2 diabetes.

MethodsWe analyzed longitudinal changes in repolarization indices of electrocardiograms in retrospectively enrolled 44 patients with type 2 diabetes and 44 age-matched healthy subjects.

ResultsIn the diabetic group, BMI was greater, levels of HbA1c 10.0 ± 1.6 vs. 5.6 ± 0.3% and triglyceride were higher and level of HDL cholesterol was lower than those in the control group. Although mean QTc intervals were similar 413.6 ± 18.5 vs. 408.3 ± 22.7 ms, QT dispersion 41.8 ± 15.4 vs. 28.7 ± 7.7 ms and Tpeak-Tend in lead V5 83.6 ± 13.6 vs. 71.3 ± 10.3 ms were significantly longer in the diabetic group than in the control group, indicating increased heterogeneity of ventricular repolarization in type 2 diabetes. During follow-up of 36 patients in the diabetic group for 787 ± 301 days, HbA1c level decreased to 7.3 ± 1.6%, while BMI did not significantly change. In contrast to HbA1c, QT dispersion 45.8 ± 15.0 ms and Tpeak-Tend in lead V5 83.6 ± 10.6 ms were not significantly reduced during the follow-up period. There was no correlation between the change in HbA1c and the change in QT dispersion or Tpeak-Tend.

ConclusionsIncreased heterogeneity of ventricular repolarization in type 2 diabetic patients was not reduced during the relatively short follow-up period despite significantly improved glycemic control.

KeywordsType 2 diabetes Glycemic control QT dispersion Ventricular repolarization AbbreviationBMIBody mass index

BPBlood pressure

DPP-4Dipeptidyl peptidase-4

ECGElectrocardiogram

HDL-CHigh-density lipoprotein cholesterol

LDL-CLow-density lipoprotein cholesterol

MIMyocardial infarction

QTcHeart rate-corrected QT interval

SCDSudden cardiac death

Tpeak-TendThe interval from the peak to the end of the T wave

Electronic supplementary materialThe online version of this article doi:10.1186-s12933-014-0125-8 contains supplementary material, which is available to authorized users.

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Autor: Takayuki Miki - Toshiyuki Tobisawa - Tatsuya Sato - Masaya Tanno - Toshiyuki Yano - Hiroshi Akasaka - Atsushi Kuno - Makoto

Fuente: https://link.springer.com/article/10.1186/s12933-014-0125-8



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