Body weight and risk of atrial fibrillation in 7,169 patients with newly diagnosed type 2 diabetes; an observational studyReportar como inadecuado

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Cardiovascular Diabetology

, 14:5

First Online: 15 January 2015Received: 29 September 2014Accepted: 28 December 2014


BackgroundObesity, type 2 diabetes and atrial fibrillation AF are closely associated, but the underlying mechanisms are not fully understood. We aimed to explore associations between body mass index BMI or weight change with risk of AF in patients with type 2 diabetes.

MethodsA total of 7,169 participations with newly diagnosed type 2 diabetes were stratified according to baseline BMI, and after a second BMI measurement within 18 months, further grouped according to relative weight change as -weight gain- >1 BMI unit -stable weight- +-− 1 BMI unit and -weight loss- <1 BMI unit. The mean follow-up period was 4.6 years, and the risk of AF was estimated using adjusted Cox regression models.

ResultsAverage age at diabetes diagnosis was 60 years and the patients were slightly obese mean BMI 30.2 kg-m. During follow-up, 287 patients developed incident AF, and those with overweight or obesity at baseline had 1.9-fold and 2.9-fold higher risk of AF, respectively, than those with normal BMI. The 14% of the patients with subsequent weight gain had 1.5-fold risk of AF compared with those with stable weight or weight loss.

ConclusionsIn patients with newly diagnosed type 2 diabetes, baseline overweight and obesity, as well as modest weight increase during the first 18 months after diagnosis, were associated with a substantially increased risk of incident AF. Patients with type 2 diabetes may benefit from efforts to prevent weight gain in order to reduce the risk of incident AF.

Trial NCT01121315

KeywordsEpidemiology Atrial fibrillation Type 2 diabetes Weight control AbbreviationsAFAtrial fibrillation

BMIBody mass index

ROSERetrospective Epidemiological Study to Investigate Outcome and Mortality with Glucose Lowering Drug Treatment in Primary Care-

CVDCardiovascular disease

APAngina pectoris

BPBlood pressure

DAGsDirected acyclic graphs

CIConfidence intervals

Electronic supplementary materialThe online version of this article doi:10.1186-s12933-014-0170-3 contains supplementary material, which is available to authorized users.

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Autor: Irene Grundvold - Johan Bodegard - Peter M Nilsson - Bodil Svennblad - Gunnar Johansson - Carl Johan Östgren - Johan Sun


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