Intraosseous concentration and inhibitory effect of different intravenous cefazolin doses used in preoperative prophylaxis of total knee arthroplastyReportar como inadecuado




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Journal of Orthopaedics and Traumatology

, Volume 16, Issue 4, pp 331–334

First Online: 02 August 2015Received: 11 September 2014Accepted: 19 July 2015

Abstract

BackgroundThe aim of this study was to compare the intraosseous concentrations and the inhibitory effects on the growth of Staphylococcus aureus of 1 g versus 2 g of intravenous IV prophylactic cefazolin in total knee arthroplasty TKA.

Materials and methodsEighteen patients 21 knees with primary knee osteoarthritis were divided into two groups receiving 1 g 12 patients: 14 knees versus 2 g six patients: seven knees IV prophylactic cefazolin prior to the incision in TKA.
Subchondral bone samples proximal tibia, distal femur were taken during the operation.
These samples were analyzed for intraosseous concentration of cefazolin and their inhibitory effects on the growth of S.
aureus, using high-performance liquid chromatography HPLC and agar disc diffusion bioassays.

ResultsThe mean intraosseous concentration in the 2 g dose group was significantly higher than in the 1 g dose group in the proximal tibia p = 0.007 and distal femur p = 0.016.
There were no significant differences between the two groups in terms of mean inhibitory effects in the proximal tibia or distal femur p > 0.05.
No significant correlations were found between the intraosseous concentrations and inhibitory effects in the proximal tibia r = 0.18, p = 0.52 and distal femur r = −0.29, p = 0.30.

ConclusionIV cefazolin at a dose of 2 g produced greater intraosseous concentrations overall than a dose of 1 g.
However, the higher intraosseous concentrations did not correlate with higher inhibitory effects.

Level of evidenceLevel III.

KeywordsCefazolin Knee arthroplasty Prophylaxis Intraosseous concentration Inhibitory Effect  Download fulltext PDF



Autor: Chayanin Angthong - Pongpaibool Krajubngern - Warawut Tiyapongpattana - Boonchana Pongcharoen - Piya Pinsornsak - Nattapol T

Fuente: https://link.springer.com/



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