A Clinical and Experimental Comparison of Time of Flight PET-MRI and PET-CT SystemsReport as inadecuate

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Molecular Imaging and Biology

, Volume 17, Issue 5, pp 714–725

First Online: 18 February 2015


PurposeThe purpose of the study was to compare image quality and quantitative accuracy of positron emission tomography-magnetic resonance imaging PET-MRI and PET-computed tomography PET-CT systems with time of flight PET gantries, using phantom and clinical studies.

ProceduresIdentical phantom experiments were performed on both systems. Calibration, uniformity, and standardized uptake value SUV recovery were measured. A clinical PET-CT versus PET-MRI comparison was performed using Ffluoromethylcholine FFCH.

ResultsCalibration accuracy and image uniformity were comparable between systems. SUV recovery met EANM-EARL requirements on both scanners. Thirty-four lesions with comparable PET image quality were identified. Lesional SUVmax differences of 4 ± 26 % between PET-MRI and PET-CT data were observed R = 0.79, slope = 1.02. In healthy tissues, PET-MRI-derived SUVs were 16 ± 11 % lower than on PET-CT R = 0.98, slope = 0.86.

ConclusionPET-MRI and PET-CT showed comparable performance with respect to calibration accuracy, image uniformity, and SUV recovery. FFCH uptake values for both healthy tissues and lesions corresponded reasonably well between MR- and CT-based systems, but only in regions free of MR-based attenuation artifacts.

Key wordsPET-MRI PET-CT Multimodality imaging Prostate cancer Ffluoromethylcholine Electronic supplementary materialThe online version of this article doi:10.1007-s11307-015-0826-8 contains supplementary material, which is available to authorized users.

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Source: https://link.springer.com/

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