18FVM4-037 MicroPET Imaging and Biodistribution of Two In Vivo CAIX-Expressing Tumor ModelsReportar como inadecuado

18FVM4-037 MicroPET Imaging and Biodistribution of Two In Vivo CAIX-Expressing Tumor Models - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Molecular Imaging and Biology

, Volume 17, Issue 5, pp 615–619

First Online: 24 February 2015


PurposeFVM4-037 was recently developed as a positron emission tomography PET tracer for the detection of carbonic anhydrase IX CAIX, a tumor-specific protein upregulated under hypoxic conditions. In this study, the accumulation of FVM4-037 was determined in two CAIX-expressing preclinical human tumor models.

ProceduresU373 and HT29 tumor-bearing animals were injected with FVM4-037 and underwent microPET imaging up to 4 h post-injection p.i

Biodistribution throughout the different organs was assessed at 2 and 4 h p.i. using gamma counting.

ResultsMicroPET imaging showed high FVM4-037 uptake in the abdominal region, and biodistribution revealed high radioactivity in the kidney, ileum, colon, liver, stomach, and bladder. Although high CAIX expression was confirmed in both tumor models, tumor uptake assessed with microPET and biodistribution experiments was comparable to background tissues.

ConclusionsIn this study, FVM4-037 does not specifically accumulate in CAIX-expressing tumors, indicating that the tracer is not suitable for the detection of CAIX.

Key wordsFVM4-037 CAIX PET imaging Biodistribution Preclinical  Download fulltext PDF

Autor: Sarah G. J. A. Peeters - Ludwig Dubois - Natasja G. Lieuwes - Dennis Laan - Martien Mooijer - Robert C. Schuit - Daniel

Fuente: https://link.springer.com/

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