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Pediatric Rheumatology

, 14:23

First Online: 18 April 2016Received: 14 January 2016Accepted: 07 April 2016


Juvenile idiopathic arthritis JIA, as a chronic condition, is associated with significant disease- and treatment-related morbidity, thus impacting children’s quality of life. In order to optimize JIA management, the paediatric rheumatologist has begun to regularly use measurements of disease activity developed, validated and endorsed by international paediatric rheumatology professional societies in an effort to monitor the disease course over time and assess the efficacy of therapeutic interventions in JIA patients.

A literature review was performed to describe the main outcome measures currently used in JIA patients to determine disease activity status.

The Juvenile Disease Activity Score JADAS, in its different versions classic JADAS, JADAS-CRP and cJADAS and the validated definitions of disease activity and response to treatment represent an important tool for the assessment of clinically relevant changes in disease activity, leading more and more to a treat-to-target strategy, based on a tight and thorough control of the patient condition. Moreover, in recent years, increasing attention on the incorporation of patient-reported or parent-reported outcomes PRCOs, when measuring the health state of patients with paediatric rheumatic diseases has emerged.

We think that the care of JIA patients cannot be possible without taking into account clinical outcome measures and, in this regard, further work is required.

KeywordsJuvenile idiopathic arthritis Outcome  Download fulltext PDF

Autor: Alessandro Consolaro - Gabriella Giancane - Benedetta Schiappapietra - Sergio Davì - Serena Calandra - Stefano Lanni - Ange


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