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Arthritis Research and Therapy

, 18:178

First Online: 02 August 2016Received: 09 May 2016Accepted: 11 July 2016


BackgroundPatients with psoriatic arthritis PsA are at an increased risk for cardiovascular CV disease.  The aim of this study was to identify the frequency of carotid plaque in asymptomatic patients with psoriatic arthritis at baseline and follow-up screening, and to assess for the impact of demonstrating plaque on management of traditional cardiovascular risk factors.

MethodsEighty-seven PsA patients underwent carotid duplex ultrasound screening. Repeat carotid duplex ultrasound was offered to all patients between 12 and 30 months. Preventive cardiology referrals were generated for all patients through the electronic health record. Traditional cardiovascular risk factors, medication use, and rates of utilization of preventive cardiology services were compared between patients with and without plaque.

ResultsCarotid plaque was identified in 34-87 39 % of PsA patients. Age and triglyceride levels were predictors of plaque presence. Patients with plaque trended toward higher rates of smoking and diabetes, and higher low-density lipoprotein levels. Only 9-87 10 % patients completed at least one visit with preventive cardiology after enrollment despite referral. Low use of statin 21 % and antiplatelet 27 % medication was observed. Rates of biologic medication use for PsA were higher 75 % than studies in similar cohorts of patients with carotid plaque. No association was seen between disease duration or activity and the presence of carotid plaque.

ConclusionDespite demonstration of high cardiac risk by the presence of carotid plaque, implementation of preventive cardiovascular services and rates of statin and antiplatelet use remained low. Age and triglyceride levels were significant variables in predicting plaque presence. There is no evidence that demonstration of plaque resulted in further evaluation or changes in treatment regimens to address heightened cardiovascular risk.

KeywordsPsoriatic arthritis Spondyloarthritis Atherosclerosis Carotid plaque  Download fulltext PDF

Autor: Michael Lucke - William Messner - Esther S. H. Kim - M. Elaine Husni


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