Pharmacokinetics of Mitomycin C Following Hepatic Arterial Chemoembolization With GelfoamReport as inadecuate

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HPB Surgery - Volume 5 1992, Issue 3, Pages 161-169

Department of Surgery, Tongji Hospital, Tongji Medical University, Wuhan 430030, China

Department of Surgery, Lund University, Lund S-221 85, Sweden

Received 1 June 1991; Accepted 1 June 1991

Copyright © 1992 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Twelve mongrel dogs were randomly allocated into two groups using matched paired-design. Catheterswere inserted into the hepatic artery, hepatic vein and the femoral vein, respectively. In the first group,gelfoam supplemented with mitomycin C MMC was injected into the hepatic artery, whereas thesecond group received a hepatic arterial injection of MMC solution alone. Simultaneous blood samplingfrom the hepatic and femoral veins at regular intervals was performed. MMC concentrations in plasmawas determined using high performance liquid chromatography HPLC and the pharmacokinetics ofMMC were determined.MMC concentrations in hepatic and femoral veins did not differ and no significant difference inpharmacokinetics was found when comparing MMC administration into the hepatic artery with orwithout gelfoam supplementation. Thus, our results revealed that gelfoam could not delay the clearanceof MMC from the liver.

Author: Jin Wen Ding, Zai de Wu, Roland Andersson, and Stig Bengmark



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