Correction of collimator-dependent differences in the heart-to-mediastinum ratio in 123I-metaiodobenzylguanidine cardiac sympathetic imaging: Determination of conversion equations using point-source imagingReportar como inadecuado




Correction of collimator-dependent differences in the heart-to-mediastinum ratio in 123I-metaiodobenzylguanidine cardiac sympathetic imaging: Determination of conversion equations using point-source imaging - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Journal of Nuclear Cardiology

pp 1–12

First Online: 01 June 2016Received: 19 March 2016Accepted: 04 May 2016

Abstract

BackgroundSeptal penetration causes collimator-dependent differences in the heart-to-mediastinum H-M ratio in I-metaiodobenzylguanidine MIBG cardiac imaging. We investigated generally applicable methods to correct such differences.

Methods and ResultsFour hours after I-MIBG injection, 40 patients underwent anterior chest imaging successively with medium-energy ME and various non-ME collimators. The H-M ratios obtained with the non-ME collimators before and after I-dual-window penetration correction were compared with the ME-derived standard values to determine patient-based conversion equations for empiric and combined corrections, respectively. A I point source was imaged with various collimators, and the central ratio, the ratio of count in a small central region of interest to count in a large one, was calculated. The method of predicting the conversion equations from the central ratios was determined. Correction using the patient-based conversion equations removed systematic underestimation of the H-M ratios obtained with the non-ME collimators, and combined correction depressed residual random errors to some degree. Point-source-based equations yielded results comparable to the patient-based equations.

ConclusionsEmpiric and combined corrections effectively reduce collimator-dependent differences in the H-M ratio. The conversion equations can be predicted from simple point-source imaging, which would allow to apply these corrections to data obtained with various collimators.

KeywordsI-metaiodobenzylguanidine MIBG collimator heart-to-mediastinum H-M ratio septal penetration AbbreviationsCHRCardiac high-resolution

IDWI-dual-window

I-MIBGI-metaiodobenzylguanidine

H-MHeart-to-mediastinum

LELow-energy

LEAPLow-energy all-purpose

LEHRLow-energy high-resolution

LMELow-medium-energy

MEMedium-energy

ROIRegion of interest

SLEHRSpecial low-energy high-resolution

See related editorial, doi:10.1007-s12350-016-0551-y

Electronic supplementary materialThe online version of this article doi:10.1007-s12350-016-0546-8 contains supplementary material, which is available to authorized users.

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Autor: Yusuke Inoue - Yutaka Abe - Kei Kikuchi - Keiji Matsunaga - Ray Masuda - Kazutoshi Nishiyama

Fuente: https://link.springer.com/



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