Polymorphism of SLC6A2 gene does not influence outcome of myocardial 123I-mIBG scintigraphy in patients with chronic heart failureReportar como inadecuado




Polymorphism of SLC6A2 gene does not influence outcome of myocardial 123I-mIBG scintigraphy in patients with chronic heart failure - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Journal of Nuclear Cardiology

pp 1–7

First Online: 14 November 2016Received: 21 August 2016Accepted: 17 October 2016

Abstract

AimThe NET, encoded by SLC6A2, is responsible for presynaptic NE-reuptake. I-mIBG is clinically used to evaluate cardiac sympathetic function. However, it is unknown if polymorphism of SLC6A2 influences cardiac sympathetic activity as assessed with I-mIBG. Therefore we studied the influence of SLC6A2 SNPs on myocardial I-mIBG parameters in CHF.

Materials and MethodsForty-nine adults with stable CHF age 66.5 ± 8.1 years, LVEF 22.3 ± 6.4 were enrolled. Fifteen minutes early and 4 hours late after administration of I-mIBG planar images were acquired. The H-M ratio was calculated from the manually drawn ROI over the left ventricle and a fixed mediastinal ROI. Fourteen exons of the SLC6A2 gene were analyzed from whole blood samples.

ResultsWe found 6 different SLC6A2 SNPs, although none were functional. LVEF was the only independent predictor for early adjusted R = 0.063, p = 0.045 and late H-M ratio adjusted R = 0.116, p = 0.010. NT-proBNP was the only independent predictor for I-mIBG WO adjusted R = 0.074, p = 0.032. SLC6A2 SNPs were not associated with any myocardial I-mIBG-derived parameter.

ConclusionIn this specific CHF population polymorphism of SLC6A2 gene was not associated with any I-mIBG derived parameters.

KeywordsCardiac sympathetic activity planar I-mIBG myocardial scintigraphy polymorphism norepinephrine transporter SLC6A2 gene Abbreviationsβ-ARβ-adrenergic receptors

H-MHeart-to-mediastinum

NENorepinephrine

NETNorepinephrine transporter

NT-proBNPN-terminal pro B-type Natriuretic Peptide

SLC6A2Solute carrier family 6

SNPSingle-nucleotide polymorphism

POTSPostural orthostatic tachycardia syndrome

ROIRegion of interest

WOWashout

Grant SupportNone of the authors has been supported by a grant.

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Autor: Derk O. Verschure - F. Baas - Berthe L. F. van Eck-Smit - G. Aernout Somsen - Hein J. Verberne

Fuente: https://link.springer.com/



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