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Arthritis Research and Therapy

, 18:283

First Online: 01 December 2016Received: 15 September 2016Accepted: 16 November 2016


BackgroundIncreasing vascular endothelial growth factor VEGF has been reported in remitting symmetrical seronegative synovitis with pitting edema RS3PE syndrome, rheumatoid arthritis RA, polymyalgia rheumatica PMR and giant cell arteritis GCA. The aim of this study was to compare VEGF levels in patients over 60 years of age who have RS3PE, RA, PMR or GCA so as to determine whether elevated VEGF is specific for a rheumatic disease, the inflammation or edema that occurs with these pathological conditions.

MethodsIn this retrospective, multicentric study we assessed serum and plasma levels of VEGF in patients over 60 years of age with rheumatic diseases that were either de novo or of recent onset according to the initial clinical presentation, and we compared these patients with a control group.

ResultsSerum and plasma VEGF levels were determined in 80 patients 5 with RS3PE, 13 with RA, 44 with PMR, and 18 with GCA and 37 controls. Edema occurred in five patients with RS3PE, four with RA, and one with PMR, but not patients with GCA. Serum VEGF levels were significantly higher in individuals with rheumatic diseases 849 405.5–1235.5 pg-ml relative to the controls 484 302–555 pg-ml p < 0.001. There were no significant differences between patients with RS3PE, RA, PMR, or GCA in terms of the VEGF serum levels p = 0.60 or plasma levels p = 0.57. Similarly, the occurrence of edema did not correlate with VEGF levels.

ConclusionVEGF increases in rheumatic diseases compared to a control group. This was not associated with specific rheumatic diseases or with edematous rheumatic diseases.

KeywordsVascular endothelial growth factor Rheumatoid arthritis Polymyalgia rheumatica Giant cell arteritis RS3PE syndrome AbbreviationsCRPC-reactive protein

ESRerythrocyte sedimentation rate

GCAgiant cell arteritis



PMRpolymyalgia rheumatica

RArheumatoid arthritis

RS3PEremitting symmetrical seronegative synovitis with pitting edema

SDstandard deviation

VEGFvascular endothelial growth factor

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Autor: Perrine Smets - Valérie Devauchelle-Pensec - Paul-Olivier Rouzaire - Bruno Pereira - Marc Andre - Martin Soubrier


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