Clinical relevance of dual-energy X-ray absorptiometry DXA as a simultaneous evaluation of fatty liver disease and atherosclerosis in patients with type 2 diabetesReportar como inadecuado




Clinical relevance of dual-energy X-ray absorptiometry DXA as a simultaneous evaluation of fatty liver disease and atherosclerosis in patients with type 2 diabetes - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Cardiovascular Diabetology

, 15:64

First Online: 14 April 2016Received: 01 March 2016Accepted: 05 April 2016

Abstract

BackgroundWhole body dual-energy X-ray absorptiometry DXA can simultaneously measure both regional fat and non-fat mass. Android-to-gynoid A-G ratio measured by DXA has been reported to be associated with cardiovascular risks and visceral adiposity; however, little is known regarding its relationship with fatty liver disease and atherosclerosis among patients with diabetes. This study was designed to investigate the association of android and gynoid fat mass measured by DXA with fatty liver disease and atherosclerosis in patients with type 2 diabetes.

MethodsThis is a cross-sectional study of 259 patients with type 2 diabetes mean age 64 ± 13 years; 40.2 % female. Android and gynoid fat mass kg were measured by DXA. Skeletal muscle index SMI was calculated as appendicular non-fat mass kg divided by height m. Visceral fat area VFA, cm, subcutaneous fat area SFA, cm, and liver attenuation index LAI were assessed by abdominal computed tomography. Intima media thickness IMT, mm in common carotid arteries was determined by carotid ultrasonography.

ResultsA-G ratio was significantly correlated with VFA r = 0.72, p < 0.001, SFA r = 0.32, p < 0.001 and LAI r = −0.26, p < 0.001. A-G ratio standardized β −0.223, p = 0.002 as well as VFA standardized β −0.226, p = 0.001 were significantly associated with LAI in the univariate model. A-G ratio remained to be significantly associated with LAI standardized β −0.224, p = 0.005 after adjusting for covariates including body mass index and transaminases. Among patients with low SMI SMI < 7.0 in male and < 5.4 in female, A-G ratio was significantly associated with carotid IMT in the multivariate model standardized β 0.408, p = 0.014.

ConclusionsDXA can be used to simultaneously estimate the risks for both fatty liver disease and atherosclerosis in patients with type 2 diabetes.

KeywordsAndoroid-to-gynoid ratio Visceral adiposity Fatty liver Atherosclerosis Type 2 diabetes AbbreviationsACRalbumin-to-creatinine ratio

A-Gandroid-to-gynoid

ALTalanine aminotransferase

ARBangiotensin receptor blocker

ASTasparatate aminotransferase

BMIbody mass index

CCBcalcium channel blocker

CIconfidence interval

CIMTcarotid intima media thickness

CTcomputed tomography

CVDcardiovascular disease

CV-RRcoefficient of variation of R–R intervals

DXAdual X-ray absorptiometry

eGFRestimated glomerular filtration rate

γ-GTPglutamyl transpeptidase

HDLhigh-density lipoprotein

HOMA-IRhomeostasis model assessment-insulin resistance

LAIliver-spleen-attenuation index

LDLlow-density lipoprotein

MRImagnetic resonance imaging

NAFLDnon-alcoholic fatty liver disease

PDRproliferative diabetic retinopathy

SFAsubcutaneous fat area

SMIskeletal muscle index

TGtriglyceride

VFAvisceral fat area

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Autor: Ryotaro Bouchi - Yujiro Nakano - Norihiko Ohara - Takato Takeuchi - Masanori Murakami - Masahiro Asakawa - Yuriko Sasahara

Fuente: https://link.springer.com/article/10.1186/s12933-016-0384-7



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