3D black blood VISTA vessel wall cardiovascular magnetic resonance of the thoracic aorta wall in young, healthy adults: reproducibility and implications for efficacy trial sample sizes: a cross-sectional studyReportar como inadecuado




3D black blood VISTA vessel wall cardiovascular magnetic resonance of the thoracic aorta wall in young, healthy adults: reproducibility and implications for efficacy trial sample sizes: a cross-sectional study - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Journal of Cardiovascular Magnetic Resonance

, 18:20

First Online: 14 April 2016Received: 19 January 2016Accepted: 22 March 2016

Abstract

BackgroundPre-clinical detection of atherosclerosis enables personalized preventive strategies in asymptomatic individuals. Cardiovascular magnetic resonance CMR has evolved as an attractive imaging modality for studying atherosclerosis in vivo. Yet, the majority of aortic CMR studies and proposed sequences to date have been performed at 1.5 tesla using 2D BB techniques and a slice thickness of 4–5 mm. Here, we evaluate for the first time the reproducibility of an isotropic, T1-weighted, three-dimensional, black-blood, CMR VISTA sequence 3D-T1-BB-VISTA for quantification of aortic wall characteristics in healthy, young adults.

MethodsIn 20 healthy, young adults 10 males, mean age 31.3 years of the AMBITYON cohort study the descending thoracic aorta was imaged with a 3.0 T MR system using the 3D-T1-BB-VISTA sequence. The inter-scan, inter-rater and intra-rater reproducibility of aortic lumen, total vessel and wall area and mean and maximum wall thickness was evaluated using Bland-Altman analyses and Intraclass Correlation Coefficients ICC. Based on these findings, sample sizes for detecting differences in aortic wall characteristics between groups were calculated.

ResultsFor each studied parameter, the inter-scan, inter-rater and intra-rater reproducibility was excellent as indicated by narrow limits of agreement and high ICCs ranging from 0.76 to 0.99. Sample sizes required to detect a 5 % difference in aortic wall characteristics between two groups were 203, 126, 136, 68 and 153 per group for lumen area, total vessel area and vessel wall area and for mean and maximum vessel wall thickness, respectively.

ConclusionThe 3D-T1-BB-VISTA sequence provides excellent reproducibility for quantification of aortic wall characteristics and can detect small differences between groups with reasonable sample sizes. Hence, it may be a valuable tool for assessment of the subtle vascular wall changes of early atherosclerosis in asymptomatic populations.

Keywords3D Black-blood CMR Reproducibility Young Healthy Atherosclerosis Aorta Characteristics Abbreviations3D-T1-BB-VISTA3 dimensional 3D black-blood BB, T1-weighted T1, turbo-spin-echo sequence with variable flip angles VISTA

AMBITYON studyAtherosclerosis Monitoring and Biomarker measurements In The YOuNg

CMRcardiovascular magnetic resonance

DIRdouble inversion recovery

ICCintra-class correlation coefficient

LOAlower and upper limit

NSAnumber of signal averaging

SDstandard deviation

SENSEsensitivity encoding

Electronic supplementary materialThe online version of this article doi:10.1186-s12968-016-0237-2 contains supplementary material, which is available to authorized users.

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Autor: Anouk L. M. Eikendal - Björn A. Blomberg - Cees Haaring - Tobias Saam - Rob J. van der Geest - Fredy Visser - Michiel 

Fuente: https://link.springer.com/article/10.1186/s12968-016-0237-2







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