Long-Term Intake of Uncaria rhynchophylla Reduces S100B and RAGE Protein Levels in Kainic Acid-Induced Epileptic Seizures RatsReportar como inadecuado




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Evidence-Based Complementary and Alternative Medicine - Volume 2017 2017, Article ID 9732854, 14 pages - https:-doi.org-10.1155-2017-9732854

Research Article

School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan

School of Post-Baccalaureate Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan

Ko Da Pharmaceutical Co. Ltd, Taoyuan 324, Taiwan

Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei 110, Taiwan

Department of Chinese Medicine, China Medical University Hospital, Taichung 40447, Taiwan

Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan

Graduate Institute of Acupuncture Science, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan

Research Center for Chinese Medicine and Acupuncture, China Medical University, Taichung 40402, Taiwan

Correspondence should be addressed to Ching-Liang Hsieh

Received 30 November 2016; Revised 13 January 2017; Accepted 24 January 2017; Published 23 February 2017

Academic Editor: Kuttulebbai N. S. Sirajudeen

Copyright © 2017 Nou-Ying Tang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Epileptic seizures are crucial clinical manifestations of recurrent neuronal discharges in the brain. An imbalance between the excitatory and inhibitory neuronal discharges causes brain damage and cell loss. Herbal medicines offer alternative treatment options for epilepsy because of their low cost and few side effects. We established a rat epilepsy model by injecting kainic acid KA, 12 mg-kg, i.p. and subsequently investigated the effect of Uncaria rhynchophylla UR and its underlying mechanisms. Electroencephalogram and epileptic behaviors revealed that the KA injection induced epileptic seizures. Following KA injection, S100B levels increased in the hippocampus. This phenomenon was attenuated by the oral administration of UR and valproic acid VA, 250 mg-kg. Both drugs significantly reversed receptor potentiation for advanced glycation end product proteins. Rats with KA-induced epilepsy exhibited no increase in the expression of metabotropic glutamate receptor 3, monocyte chemoattractant protein 1, and chemokine receptor type 2, which play a role in inflammation. Our results provide novel and detailed mechanisms, explaining the role of UR in KA-induced epileptic seizures in hippocampal CA1 neurons.





Autor: Nou-Ying Tang, Yi-Wen Lin, Tin-Yun Ho, Chin-Yi Cheng, Chao-Hsiang Chen, and Ching-Liang Hsieh

Fuente: https://www.hindawi.com/



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