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Cardiovascular Diabetology

, 15:66

First Online: 20 April 2016Received: 04 February 2016Accepted: 07 April 2016

Abstract

BackgroundMicrovascular function is impaired in patients with stable coronary artery disease. The aim was to study microvascular function in patients with diabetes and acute coronary syndrome ACS.

MethodsMicrovascular function was evaluated in 83 patients by laser Doppler fluxmetry LDF PU; perfusion unit, median interquartile range measuring resting LDF and peak LDF following a six min heating of the skin to 44 °C at the foot, respectively. All patients with ACS and without previously known diabetes underwent oral glucose tolerance test. Thirty-nine patients with type 2 diabetes mellitus free from coronary artery disease served as controls.

ResultsPeak LDF was significantly P = 0.03 lower in patients with ACS and diabetes n = 22; 72 52 and diabetes without coronary artery disease n = 39; 69 51 as compared to patients with ACS without diabetes n = 46; 97 60, and patients without ACS n = 15; 140 121, respectively. Patients with ACS n = 68 had significantly P = 0.04 lower peak LDF 92 49 as compared to patients without ACS n = 15 140 121.

ConclusionMicrovascular reactivity is severely impaired in patients with diabetes and ACS. Diabetes has a major influence on microvascular function in patients with coronary artery disease.

KeywordsMicrovascular reactivity Coronary artery disease Acute coronary syndrome Diabetes mellitus Laser Doppler fluxmetry  Download fulltext PDF



Autor: Nikolaos Östlund Papadogeorgos - Gun Jörneskog - Mattias Bengtsson - Thomas Kahan - Majid Kalani

Fuente: https://link.springer.com/article/10.1186/s12933-016-0385-6



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