Recurrent Acute Pancreatitis Probably Induced by Rosuvastatin Therapy: A Case ReportReport as inadecuate

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Case Reports in MedicineVolume 2012 2012, Article ID 973279, 4 pages

Case ReportWright Center for Graduate Medical Education, 501 Madison Ave, Scranton, PA 18510, USA

Received 30 January 2012; Accepted 13 February 2012

Academic Editor: Tobias Keck

Copyright © 2012 JayaKrishna Chintanaboina and Deepa Gopavaram. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Context. Approximately 1.4–2% of all cases of acute pancreatitis are drug related in general population. The literature on statin-induced pancreatitis consists primarily of anecdotal case reports. We report a case of possible rosuvastatin-induced pancreatitis. Case Report. A 67-year-old female presented with progressively worsening abdominal pain and vomiting for 7 days. Home medications included rosuvastatin and clonidine. CT scan of abdomen, with intravenous contrast, showed findings consistent with acute pancreatitis. She responded to conservative management. Rosuvastatin was resumed at the time of discharge from the hospital, and she presented two months later with recurrence of acute pancreatitis. Further workup ruled out all likely causes of acute pancreatitis. Rosuvastatin was stopped completely when she was discharged the second time, and she did not have any further episodes of acute pancreatitis. She was completely asymptomatic throughout the 18-month follow-up period. Conclusion. This paper reinforces the possible association of rosuvastatin, a novel statin, with acute pancreatitis, even though the exact underlying mechanism of statin-induced pancreatitis remains unknown.

Author: JayaKrishna Chintanaboina and Deepa Gopavaram



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