Long-term efficacy of ultrasound-guided high-intensity focused ultrasound treatment of breast fibroadenomaReport as inadecuate

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Journal of Therapeutic Ultrasound

, 5:1

First Online: 16 March 2017Received: 21 September 2016Accepted: 06 January 2017


BackgroundTo assess the long term efficacy and tolerability of one or two ultrasound US-guided high-intensity focused ultrasound HIFU treatment in patients with breast fibroadenoma FA.

MethodsTwenty patients with 26 FA were selected for US-guided HIFU. The therapy was performed in one or two sessions. FA volume was assessed before and followed up to 24 months after the last HIFU. After each treatment, adverse events were evaluated.

ResultsIn 19-26 FA 73.1% one HIFU was performed group 1, whereas 7-26 FA 26.9% received second HIFU group 2 6-9 months median, 7 months after the first session. In group 1 and 2, FA volume decreased significantly at 1-month p < 0.001 and 3-month follow-up p = 0.005, respectively, and continued to reduce until 24-month follow-up p < 0.001 and p = 0.003, respectively. At 24 months, mean volume reduction was 77.32% in group 1 and 90.47% in group 2 p = 0.025. Mild subcutaneous edema was observed in 4 patients and skin erythema in 3 patients.

ConclusionsUS-guided HIFU represents a promising non-invasive method with sustainable FA volume reduction and patient’s tolerability. Although one treatment is highly efficient, the volume reduction can be increased with second treatment.

Trial registrationNCT01331954. Registered 07 April 2011.

KeywordsBreast fibroadenoma High-intensity focused ultrasound HIFU Ultrasound US guidance Ablation techniques Interventional ultrasonography AbbreviationsBI-RADSBreast imaging and reporting data system

BMIBody mass index

CFDColour flow Doppler


HIFUHigh-intensity focused ultrasound

MRMagnetic resonance

SDStandard deviation


VASVisual analog scale.

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Author: Roussanka Kovatcheva - Katja Zaletel - Jordan Vlahov - Julian Stoinov

Source: https://link.springer.com/


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