Relationship between native papillary muscle T1 time and severity of functional mitral regurgitation in patients with non-ischemic dilated cardiomyopathyReport as inadecuate




Relationship between native papillary muscle T1 time and severity of functional mitral regurgitation in patients with non-ischemic dilated cardiomyopathy - Download this document for free, or read online. Document in PDF available to download.

Journal of Cardiovascular Magnetic Resonance

, 18:79

First Online: 16 November 2016Received: 21 July 2016Accepted: 29 October 2016

Abstract

BackgroundFunctional mitral regurgitation is one of the severe complications of non-ischemic dilated cardiomyopathy DCM. Non-contrast native T1 mapping has emerged as a non-invasive method to evaluate myocardial fibrosis. We sought to evaluate the potential relationship between papillary muscle T1 time and mitral regurgitation in DCM patients.

MethodsForty DCM patients 55 ± 13 years and 20 healthy adult control subjects 54 ± 13 years were studied. Native T1 mapping was performed using a slice interleaved T1 mapping sequence STONE which enables acquisition of 5 slices in the short-axis plane within a 90 s free-breathing scan. We measured papillary muscle diameter, length and shortening. DCM patients were allocated into 2 groups based on the presence or absence of functional mitral regurgitation.

ResultsPapillary muscle T1 time was significantly elevated in DCM patients with mitral regurgitation n = 22 in comparison to those without mitral regurgitation n = 18 anterior papillary muscle: 1127 ± 36 msec vs 1063 ± 16 msec, p < 0.05; posterior papillary muscle: 1124 ± 30 msec vs 1062 ± 19 msec, p < 0.05, but LV T1 time was similar 1129 ± 38 msec vs 1134 ± 58 msec, p = 0.93. Multivariate linear regression analysis showed that papillary muscle native T1 time β = 0.10, 95 % CI: 0.05–0.17, p < 0.05 is significantly correlated with mitral regurgitant fraction. Elevated papillary muscle T1 time was associated with larger diameter, longer length and decreased papillary muscle shortening all p values <0.05.

ConclusionsIn DCM, papillary muscle native T1 time is significantly elevated and related to mitral regurgitant fraction.

AbbreviationsANOVAAnalysis of variance

ARCTICAdaptive registration of varying contrast-weighted images for improved tissue characterization

CIConfidence interval

CMRCardiovascular magnetic resonance

CVCoefficient of variation

DCMDilated cardiomyopathy

ECVExtracellular volume

FAFlip angle

FOVField of view

LALeft atrial

LGELate gadolinium enhancement

LVLeft ventricular

MRMitral regurgitation

ROIRegion of interest

SDStandard deviation

SENSESensitivity encoding

SSFPSteady-state free precession

STONESlice-interleaved T1

TEEcho time

TFETurbo field echo

TRRepetition time

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Author: Shingo Kato - Shiro Nakamori - Sébastien Roujol - Francesca N. Delling - Shadi Akhtari - Jihye Jang - Tamer Basha - Sophi

Source: https://link.springer.com/article/10.1186/s12968-016-0301-y







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