Routine 18F-FDG PET-CT does not detect inflammation in the left atrium in patients with atrial fibrillationReportar como inadecuado




Routine 18F-FDG PET-CT does not detect inflammation in the left atrium in patients with atrial fibrillation - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

The International Journal of Cardiovascular Imaging

, Volume 33, Issue 8, pp 1271–1276

First Online: 22 February 2017Received: 13 October 2016Accepted: 06 February 2017

Abstract

Increasing evidence supports a role of inflammation in the development of atrial fibrillation AF. However, direct evidence of persistent inflammatory activity in the atria of AF patients is scarce. In this study, we used 18-Fluor-Deoxyglucose positron emission tomography computed tomography F-FDG PET-CT to determine atrial inflammation in patients with and without AF. Retrospectively, F-FDG PET-CT scans were analyzed. 37 patients with a history of AF were compared to an age and sex matched control group with no history of AF. Standardized uptake values were obtained in the atrial walls, in the left ventricular wall, and in the right ventricular blood pool, respectively. Target to background ratios TBR were determined in the atrial and left ventricular walls and compared between the two groups. TBR values of the left atrial wall were slightly but not significantly higher in patients with AF 1.21 ± 0.27 compared to those without AF 1.14 ± 0.29; p = 0.85. Likewise, a weak but not significant difference was observed in signal intensities in the right atrial wall between patients in the AF 1.14 ± 0.45 and the control group 0.96 ± 0.2; p = 0.41. TBR values of the left ventricular myocardium did not differ between the groups; no significant correlation was found between the TBR in the left and right atrial wall and blood glucose levels. F-FDG PET-CT performed under routine conditions did not detect a significant difference in inflammatory activity in the left or right atrium between patients with and without AF. Contrary to previous reports, these results therefore do not clearly support a role for ongoing atrial inflammation in patients with AF. Prospective clinical studies using myocardial glucose uptake suppression strategies may be helpful to clarify these issues.

KeywordsAtrial fibrillation Inflammation Positron emission tomography Cardiac imaging Philipp S. Lange, Nemanja Avramovic, Lars Eckardt, and Christian Wenning have contributed equally to this work.

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Autor: Philipp S. Lange - Nemanja Avramovic - Gerrit Frommeyer - Kristina Wasmer - Christian Pott - Lars Eckardt - Christian Wenn

Fuente: https://link.springer.com/



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