Potential Mediators between Fibromyalgia and C-Reactive protein: Results from a Large U.S. Community SurveyReportar como inadecuado




Potential Mediators between Fibromyalgia and C-Reactive protein: Results from a Large U.S. Community Survey - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Musculoskeletal Disorders

, 18:294

Epidemiology of musculoskeletal disorders

Abstract

BackgroundFibromyalgia, a potentially debilitating chronic pain syndrome of unknown etiology, may be characterized by inflammation. In this study, we investigated the relation of FMS to serum C-reactive protein CRP in a large population of adults 18+ and investigated the influence of other factors on this relationship, including BMI, comorbidities, as well as mood and sleep disturbance.

MethodsParticipants were 52,535 Ohio Valley residents Fibromyalgia n = 1125. All participants completed a comprehensive health survey 2005–2006 part of the C8 Health Project; serum levels of CRP were obtained, as was history of Fibromyalgia physician diagnosis. Logistic and linear regressions were used for this cross-sectional analysis.

ResultsMean CRP was higher among participants reporting Fibromyalgia than those without 5.54 ± 9.8 vs.3.75 ± 7.2 mg-L, p < .0001. CRP level showed a strong, positive association with FMS unadjusted odds ratio OR for highest vs. lowest quartile = 2.5 CI 2.1,3.0;p for trend < .0001; adjustment for demographic and lifestyle factors attenuated but did not eliminate this association AOR for highest vs. lowest quartile = 1.4 CI 1.1,1.6;p for trend < .0001. Further addition of body mass index BMI and comorbidities to the model markedly weakened this relationship AORs, respectively, for highest vs lowest CRP quartile = 1.2 CI 1.0,1.4 and 1.1 CI 0.9,1.3. In contrast, inclusion of mood and sleep impairment only modestly reduced the adjusted risk estimate AORs for highest vs. lowest quartile = 1.3 CI 1.1,1.5 for each.

ConclusionsFindings from this large cross-sectional study indicate a significant positive cross-sectional association of Fibromyalgia to serum C-reactive protein may be explained, in part, by BMI and comorbidity. Prospective research is needed to confirm this, and clarify the potential mediating influence of obesity and comorbid conditions on this relationship.

KeywordsFibromyalgia C-reactive protein Inflammation Body mass index Comorbidity Mediator Epidemiology AbbreviationsBMIBody Mass Index

CRPC-reactive protein

FMSFibromyalgia syndrome

PFOAPerfluorooctanoic Acid

WVUWest Virginia University

Download fulltext PDF



Autor: Termeh Feinberg - Usha Sambamoorthi - Christa Lilly - Kim Karen Innes

Fuente: https://link.springer.com/







Documentos relacionados