Glutamate transporters prevent the generation of seizures in the developing rat neocortex.Report as inadecuate




Glutamate transporters prevent the generation of seizures in the developing rat neocortex. - Download this document for free, or read online. Document in PDF available to download.

* Corresponding author 1 Epilepsie et ischémie cérébrale

Abstract : Glutamate transporters are operative at an early developmental stage well before synapse formation, but their functional significance has not been determined. We now report that blockade of glutamate transporters in the immature neocortex generates recurrent NMDA receptor-mediated currents associated with synchronous oscillations of Ca2+i in the entire neuronal population. Intracerebroventricular injections of the blocker to pups generate seizures that are prevented by coinjections of NMDA receptor blockers. Therefore, the early expression of glutamate transporters plays a central role to prevent the activation by local glutamate concentrations of NMDA receptors and the generation of seizures that may alter the construction of cortical networks. A dysfunction of glutamate transporters may be a central event in early infancy epilepsy syndromes.

Keywords : cortex epilepsy network synchrony transport N-methyl-D-aspartate





Author: Michael Demarque - Nathalie Villeneuve - Jean-Bernard Manent - Hélène Becq - Alfonso Represa - Yehezkel Ben-Ari - Laurent Aniks

Source: https://hal.archives-ouvertes.fr/



DOWNLOAD PDF




Related documents