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BioMed Research InternationalVolume 2014 2014, Article ID 851820, 6 pages

Research Article

División de Neurociencias, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, 44340 Guadalajara, JAL, Mexico

Departamento de Clínicas Médicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, 44350 Guadalajara, JAL, Mexico

Maestría en Nutrición Clínica, Universidad del Valle de Atemajac, 45050 Zapopan, JAL, Mexico

Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Instituto de Biología Molecular en Medicina y Terapia Génica, Universidad de Guadalajara, 44350 Guadalajara, JAL, Mexico

Unidad Médica de Alta Especialidad, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, 44340 Guadalajara, JAL, Mexico

Departamento de Clínicas Odontológicas Integrales, Centro Universitario de Ciencias de la Salud, Instituto de Investigación en Odontología, Universidad de Guadalajara, 44350 Guadalajara, JAL, Mexico

Departamento de Neonatología, Unidad Médica de Alta Especialidad, Hospital de Pediatría, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, 44340 Guadalajara, JAL, Mexico

Laboratorio de Mutagénesis, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Sierra Mojada 800, Colonia Independencia, 44340 Guadalajara, JAL, Mexico

Received 12 February 2014; Accepted 10 May 2014; Published 25 May 2014

Academic Editor: Lucia Lopalco

Copyright © 2014 Blanca Miriam Torres-Mendoza et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The use of raltegravir in treating HIV-AIDS has been proposed due to its effectiveness in suppressing high loads of HIV RNA in pregnant women, thus preventing infection of the fetus. However, administration of raltegravir during pregnancy produces a compound which is transferred to high concentrations to the offspring. The objective of this study is to evaluate the transplacental genotoxic effect of raltegravir in newborn rats. We evaluated the number of micronucleated erythrocytes MNE, micronucleated polychromatic erythrocytes MNPCE, and polychromatic erythrocytes PCE in the peripheral blood samples of the offspring of Wistar rats treated 6 days before birth with oral administration of raltegravir. The animals were randomly assigned to five groups as follows: raltegravir at doses of 15, 30, or 60 mg-day, cyclophosphamide 10 mg-kg positive control, or 0.5 ml of sterile water negative control. In addition, the effect of these drugs on the weight and height of newborns was assessed. There were no differences in the number of MNE, MNPCE, and PCE, and a slight decrease in the weight and height was observed in the offspring of the rat mothers treated with raltegravir. Genotoxicity studies are required in pregnant women to determine the risk of using raltegravir to the fetuses.





Autor: Blanca Miriam Torres-Mendoza, Damharis Elizabeth Coronado-Medina, Belinda Claudia Gómez-Meda, Eduardo Vázquez-Valls, Ana Lou

Fuente: https://www.hindawi.com/



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