Pattern and Determinants of Antiretroviral Drug Adherence among Nigerian Pregnant WomenReport as inadecuate

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Journal of PregnancyVolume 2012 2012, Article ID 851810, 6 pages

Research Article

Clinical Sciences Division, Nigerian Institute of Medical Research, P.M.B 2013, Yaba, Lagos, Nigeria

Department of Clinical and Biopharmacy, Faculty of Pharmacy, University of Lagos, P.M.B 12003, Surulere, Lagos, Nigeria

Received 4 August 2011; Revised 24 November 2011; Accepted 9 December 2011

Academic Editor: Karen Odberg-Petterson

Copyright © 2012 S. O. Ekama et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. The need for a high level of adherence to antiretroviral drugs has remained a major hurdle to achieving maximal benefit from its use in pregnancy. This study was designed to determine the level of adherence and identify factors that influence adherence during pregnancy. Method. This is a cross-sectional study utilizing a semistructured questionnaire. Bivariate and multiple logistic regression models were used to determine factors independently associated with good drug adherence during pregnancy. Result. 137 80.6% of the interviewed 170 women achieved adherence level of ≥95% using 3 day recall. The desire to protect the unborn child was the greatest motivation 51.8% for good adherence. Fear of being identified as HIV positive 63.6% was the most common reason for nonadherence. Marital status, disclosure of HIV status, good knowledge of ART, and having a treatment supporter were found to be significantly associated with good adherence at bivariate analysis. However, after controlling for confounders, only HIV status disclosure and having a treatment partner retained their association with good adherence. Conclusion. Disclosure of HIV status and having treatment support are associated with good adherence. Maternal desire to protect the child was the greatest motivator for adherence.

Author: S. O. Ekama, E. C. Herbertson, E. J. Addeh, C. V. Gab-Okafor, D. I. Onwujekwe, F. Tayo, and O. C. Ezechi



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