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Case Reports in ImmunologyVolume 2012 2012, Article ID 272303, 3 pages

Case Report

Department of Rheumatology and Clinical Immunology, Asklepios Clinic, 93077 Bad Abbach, Germany

Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany

Department of Pulmonology and Internal Medicine II, University of Regensburg, 93042 Regensburg, Germany

Received 15 August 2012; Accepted 3 October 2012

Academic Editors: N. Kutukculer, T. Manigold, and A. Plebani

Copyright © 2012 Wolfgang Hartung et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Rheumatoid arthritis- RA- associated interstitial lung disease RA-ILD is the extra-articular complication with most adverse impact on the quality of life and survival in RA patients. However, treatment options are limited and controlled studies are lacking. Here, we present the case of a 66-year-old patient suffering from severe RA-ILD, which has been successfully treated with Rituximab RTX. After failure of conventional DMARD therapy, our patient showed sustained improvement of clinical pulmonary parameters as well as joint inflammation following B-cell depletion with RTX. The six-minute-walk test improved from 380 meters to 536 meters and the forced vital capacity from 2.49 liters to 3.49. The disease activity score could be reduced from 7.7 to 2.8. Therefore, RTX might be considered as an alternative treatment for RA-ILD in patients not responding to conventional DMARD therapy.





Autor: Wolfgang Hartung, Judith Maier, Michael Pfeifer, and Martin Fleck

Fuente: https://www.hindawi.com/



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