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Canadian Journal of Infectious Diseases - Volume 7 1996, Issue 4, Pages 253-258

Original Article Department of Medicine, Victoria General Hospital, Dalhousie University, Halifax, Nova Scotia, Canada

Received 28 August 1995; Accepted 28 February 1996

Copyright © 1996 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

OBJECTIVE: To compare community-acquired pneumonia CAP in hospitalized human immunodeficiency virus HIV-infected patients with that in hospitalized non-HIV-infected patients by assessing presenting characteristics, etiology and outcomes.

DESIGN: Retrospective chart review.

SETTING: A tertiary care centre in Halifax, Nova Scotia.

POPULATION STUDIED: Thirty-two HIV-infected patients requiring hospitalization for treatment of CAP were identified from September 1991 to October 1993 and compared with 33 age-matched non-HIV-infected patients who presented with pneumonia during the same period.

MAIN RESULTS: The two populations were comparable in age, sex and race. Fifty per cent of the HIV-infected and 20.8% of the non-HIV-infected patients had had a previous episode of pneumonia. Pneumocystis carinii pneumonia PCP accounted for 16 of the 32 episodes of CAP in the HIV-infected patients, while none of the non-HIV-infected patients had PCP. Pneumonia secondary to Streptococcus pneumoniae was more common in the non-HIV-infected patients five versus one, P=0.02. Vital signs and initial PO2 did not differ between the two groups. White blood cell count was lower at admission for the HIV population 5.7×10

-L versus 12.7×10

-L, P=0.003. The HIV patients were more likely to undergo bronchoscopy 27.7% versus 0%, P<0.001. The length of stay in hospital, transfer to the intensive care unit and necessity for intubation were the same for both groups. The in-hospital mortality for HIV-infected patients was eight of 32 25% while for the non-HIV-infected patients it was none of 33 P=0.002.

CONCLUSIONS: Patients with HIV infection who present with CAP are more likely to have PCP, to have had a past episode of pneumonia and to die while in hospital than age- and sex-matched non-HIV-infected patients with CAP.





Autor: Claire Touchie and Thomas J Marrie

Fuente: https://www.hindawi.com/



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