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Journal of OncologyVolume 2010 2010, Article ID 272170, 7 pages

Review Article

Laboratory of Investigation, Molecular Biology Unit, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, 28006-Madrid, Spain

Hepatology Unit, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, 28006 Madrid, Spain

CIBERehd, Instituto de Salud Carlos III, 28006 Madrid, Spain

Received 18 November 2009; Revised 24 February 2010; Accepted 16 March 2010

Academic Editor: Arkadiusz Dudek

Copyright © 2010 Paloma Sanz-Cameno et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Recently, new information relating to the potential relevance of chronic hepatic inflammation to the development and progression of hepatocellular carcinoma HCC has been generated. Persistent hepatocellular injury alters the homeostatic balance within the liver; deregulation of the expression of factors involved in wound healing may lead to the evolution of dysplastic lesions into transformed nodules. Progression of such nodules depends directly on the development and organization of a vascular network, which provides the nutritional and oxygen requirements to an expanding nodular mass. Angiogenic stimulation promotes intense structural and functional changes in liver architecture and physiology, in particular, it facilitates transformation of dysplasia to nodular lesions with carcinogenic potential. HCC depends on the growth and spreading of vessels throughout the tumor. Because these vascular phenomena correlate with disease progression and prognosis, therapeutic strategies are being developed that focus on precluding vascular expansion in these tumors. Accordingly, an in-depth study of factors that promote and support pathological angiogenesis in chronic hepatic diseases may provide insights into methods of preventing the development of HCC and-or stimulating the regression of established HCC.

Autor: Paloma Sanz-Cameno, María Trapero-Marugán, María Chaparro, Evan Anthony Jones, and Ricardo Moreno-Otero



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