Molecular Targets and Associated Potential Pathways of Danlu Capsules in Hyperplasia of Mammary Glands Based on Systems PharmacologyReportar como inadecuado




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Evidence-Based Complementary and Alternative Medicine - Volume 2017 2017, Article ID 1930598, 10 pages - https:-doi.org-10.1155-2017-1930598

Research Article

Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong

Suzhong Pharmaceutical Group Co., Ltd., Taizhou 225500, China

Correspondence should be addressed to Kun Wang and Qingshan Zheng

Received 4 January 2017; Revised 31 March 2017; Accepted 23 April 2017; Published 23 May 2017

Academic Editor: Olumayokun A. Olajide

Copyright © 2017 Jihan Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hyperplasia of mammary glands HMG is common in middle-aged women. Danlu capsules DLCs can effectively relieve pain and improve clinical symptoms and are safe for treating HMG. However, the active substances in DLCs and the molecular mechanisms of DLCs in HMG remain unclear. This study identified the bioactive compounds and delineated the molecular targets and potential pathways of DLCs by using a systems pharmacology approach. The candidate compounds were retrieved from the traditional Chinese medicine systems pharmacology TCMSP database and analysis platform. Each candidate’s druggability was analyzed according to its oral bioavailability and drug-likeness indices. The candidate proteins and genes were extracted in the TCMSP and UniProt Knowledgebase, respectively. The potential pathways associated with the genes were identified by performing gene enrichment analysis with DAVID Bioinformatics Resources 6.7. A total of 603 compounds were obtained from DLCs, and 39 compounds and 66 targets associated with HMG were obtained. Gene enrichment analysis yielded 10 significant pathways with 34 targets. The integrated HMG pathway revealed that DLCs probably act in patients with HMG through multiple mechanisms of anti-inflammation, analgesic effects, and hormonal regulation. This study provides novel insights into the mechanisms of DLCs in HMG, from the molecular level to the pathway level.





Autor: Jihan Huang, Haitao Tang, Sumin Cao, Yingchun He, Yibin Feng, Kun Wang, and Qingshan Zheng

Fuente: https://www.hindawi.com/



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