Emodin, a Naturally Occurring Anthraquinone Derivative, Ameliorates Dyslipidemia by Activating AMP-Activated Protein Kinase in High-Fat-Diet-Fed RatsReportar como inadecuado




Emodin, a Naturally Occurring Anthraquinone Derivative, Ameliorates Dyslipidemia by Activating AMP-Activated Protein Kinase in High-Fat-Diet-Fed Rats - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Evidence-Based Complementary and Alternative MedicineVolume 2012 2012, Article ID 781812, 9 pages

Research Article

Department of Internal Medicine, Pao Chien Hospital, Pingtung City, Pingtung County 90064, Taiwan

Traditional Medicinal Center, Kaohsiung Veterans General Hospital, Kaohsiung City 81362, Taiwan

Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Yanpu Shiang, Ping Tung Shien 90701, Taiwan

School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 40402, Taiwan

Received 15 January 2012; Accepted 29 February 2012

Academic Editor: Angelo Antonio Izzo

Copyright © 2012 Thing-Fong Tzeng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of this study was to investigate the antiobesity and antihyperlipidaemic effects of emodin on high-fat diet HFD-induced obese rats, and on the regulation of the expression of the genes involved in lipid metabolism to elucidate the mechanisms. After being fed HFD for two weeks, Wistar rats were dosed orally with emodin 40 and 80 mg kg

or pioglitazone 20 mg kg

, once daily for eight weeks. Emodin 80 mg kg

per day displayed similar characteristics to pioglitazone 20 mg kg

per day in reducing body weight gain, plasma lipid levels as well as coronary artery risk index and atherogenic index of HFD-fed rats. Emodin also caused dose related reductions in the hepatic triglyceride and cholesterol contents and lowered hepatic lipid droplets accumulation in HFD-fed rats. Emodin and pioglitazone enhanced the phosphorylation of AMP-activated protein kinase AMPK and its primary downstream targeting enzyme, acetyl-CoA carboxylase, up-regulated gene expression of carnitine palmitoyl transferase 1, and down-regulated sterol regulatory element binding protein 1 and fatty acid synthase protein levels in hepatocytes of HFD-fed rats. Our findings suggest emodin could attenuate lipid accumulation by decreasing lipogenesis and increasing mitochondrial fatty acid β-oxidation mediated by activation of the AMPK signaling pathway.





Autor: Thing-Fong Tzeng, Hung-Jen Lu, Shorong-Shii Liou, Chia Ju Chang, and I-Min Liu

Fuente: https://www.hindawi.com/



DESCARGAR PDF




Documentos relacionados