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International Journal of PeptidesVolume 2012 2012, Article ID 781785, 3 pages

Research ArticleSI “Institute of Pharmacology and Toxicology” National Academy of Medical Sciences of Ukraine, Eugene Potier 14, 03680 Kyiv, Ukraine

Received 5 December 2011; Revised 13 February 2012; Accepted 16 February 2012

Academic Editor: Katsuhiro Konno

Copyright © 2012 Larysa B. Bondarenko and Valentina M. Kovalenko. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. Current therapeutic regimens with first-line antitubercular agents are associated to a high rate of adverse effects which could cause pronounced changes in collagen-s contents and structure. Investigation of these changes is very important for optimization of antitubercular therapy and minimization of treatment-caused harm. The aim of present paper was to investigate potential effect of pyrazinamide on male rats- cartilage type II collagen amino acid composition. Materials and Methods. Wistar albino male rats 160–200 g b.w. were divided into three groups: I—received pyrazinamide per os at a dose of 1000 mg-kg b.w.-day; II—at a dose of 2000 mg-kg b.w.-day, in both groups it was given for 60 days; III—control. After 60 days of the experiment, rats of the experimental groups I and II and control groups were sacrificed and the amino acids contents of male rat cartilage type II collagens were determined using amino acid analyzer. Results and Discussion. The study of pyrazinamide effects administered in different doses on rat cartilage type II collagen amino acid contents demonstrated presence of dose-dependent pyrazinamide-mediated quantitative and qualitative changes in these rat extracellular matrix proteins in comparison with control.

Autor: Larysa B. Bondarenko and Valentina M. Kovalenko



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