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Journal of Immunology Research - Volume 2015 2015, Article ID 675269, 7 pages -

Review ArticleDepartment of Pediatrics, Hematology-Oncology, University of Louisville, Louisville, KY 40202, USA

Received 31 July 2015; Accepted 31 August 2015

Academic Editor: Fabio Pastorino

Copyright © 2015 Michael A. Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Progress in the use of traditional chemotherapy and radiation-based strategies for the treatment of pediatric malignancies has plateaued in the past decade, particularly for patients with relapsing or therapy refractory disease. As a result, cellular and humoral immunotherapy approaches have been investigated for several childhood cancers. Several monoclonal antibodies are now FDA approved and commercially available, some of which are currently considered standard of practice. There are also several new cellular immunotherapy approaches under investigation, including chimeric antigen receptor CAR modified T cells, cancer vaccines and adjuvants, and natural killer NK cell therapies. In this review, we will discuss previous studies on pediatric cancer immunotherapy and new approaches that are currently being investigated in clinical trials.

Autor: Michael A. Huang, Deepa K. Krishnadas, and Kenneth G. Lucas

Fuente: https://www.hindawi.com/


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