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Mediators of Inflammation - Volume 2 1993, Issue 6, Pages 403-406

Research paper Research Department, Spezialklinik Neukirchen, Neukirchen, 93453, Germany

Received 9 July 1993; Accepted 10 August 1993

Copyright © 1993 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Increased plasma histamine levels were associated with significantly lowered diamine and type B monoamine oxidase activities in platelet-rich plasma of atopic eczema AE patients. The diamine oxidase has almost normal cofactor levels pyridoxal phosphate and Cu

but the cofactor levels for type B monoamine oxidase flavin adenine dinucleotide and Fe

are lowered. The biogenic amines putrescine, cadaverine, spermidine, spermine, tyramine and serotonin in the sera, as well as dopamine and epinephrine in EDTA-plasma were found to be normal. It is unlikely, therefore, that these amines are responsible for the decreased activities of monoamine and diamine oxidase in these patients. The most likely causative factors for the inhibition of the diamine oxidase are nicotine, alcohol, food additives and other environmental chemicals, or perhaps a genetic defect of the diamine oxidase.

Autor: Reinhold Kiehl and Gruia Ionescu



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