Diagnostic Potential of Distortion Product Otoacoustic Emissions in Noninvasive Assessment of Elevated Intracranial Pressure: Different Patterns of DPOAE Alterations in the Guinea PigReportar como inadecuado




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ISRN AnesthesiologyVolume 2011 2011, Article ID 596848, 6 pages

Research Article

Department of Otorhinolaryngology, Head and Neck Surgery, Technical University of Munich, Ismaningerstraße 22, 81675 Munich, Germany

Walter Brendel Centre for Experimental Medicine, Ludwig Maximilians University of Munich, Marchioninistraße 15, 81377 Munich, Germany

Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig Maximilians University of Munich, Marchioninistraße 15, 81377 Munich, Germany

Department of Neurosurgery, Ludwig Maximilians University of Munich, Marchioninistraße 15, 81377 Munich, Germany

Received 31 October 2011; Accepted 5 December 2011

Academic Editors: S. Baris and E. Shipton

Copyright © 2011 Ulrich Strassen et al.
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Distortion product otoacoustic emissions DPOAEs have been proposed for monitoring the intracranial pressure ICP noninvasively.
Aim of this study was to establish an animal model in the guinea pig for a detailed characterisation of ICP-related DPOAE alterations.
In guinea pigs, the ICP was elevated experimentally and the DPOAE levels were continuously monitored.
Two different patterns of DPOAE level changes were observed: 1 a decrease of few decibels affecting mainly the frequency 𝑓 2 = 2 kHz with instant recovery after normalization of ICP, probably related to alterations of middle ear sound transmission; 2 a more pronounced level decrease affecting all frequencies, combined with a second decrease and prolonged recovery after ICP normalization, which might be related to alterations of the cochlear blood flow.
Alterations of the levels of DPOAEs might not only provide information about ICP but also indicate criticalICP-induced reductions of the cochlear and the cerebral perfusion pressure.





Autor: Ulrich Strassen, Christoph Deppe, Klaus Mees, Nikolaus Plesnila, Martin Canis, Sebastian Strieth, and Bernhard Olzowy

Fuente: https://www.hindawi.com/



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