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Disease Markers - Volume 30 2011, Issue 2-3, Pages 123-132



Veteran’s Affairs Medical Center, San Francisco, CA, USA

Northern California Institute for Research and Education, San Francisco, CA, USA

Department of Psychiatry, University of California, San Francisco, CA, USA

Department of Laboratory Medicine, University of California, San Francisco, CA, USA

Department of Medicine, University of California, Los Angeles, CA, USA

Received 14 April 2011; Accepted 14 April 2011

Copyright © 2011 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Post-traumatic stress disorder PTSD confers an increased risk for disorders with an inflammatory etiology. PTSD-related dysregulation of the sympathetic nervous system SNS and hypothalamic-pituitary adrenal HPA axis and associated alterations in inflammatory activity may contribute to this increased risk. However, little is known about convergent SNS, HPA and inflammatory signaling at the level of the immune cell transcriptome in PTSD. To explore such signaling, we examined the prevalence of specific transcription factor binding motifs in the promoter regions of differentially expressed genes in monocytes from individuals with PTSD and matched controls. Participants included 49 men 24 PTSD+ and 25 trauma-exposed controls and 18 women 10 PTSD+ and 8 controls. Men with PTSD showed up-regulation of target genes for the NF-κB-Rel family of transcription factors, which convey inflammatory signals, up-regulation of target genes for CREB-ATF transcription factors, which convey adrenergic signals from the SNS, and down-regulation of target genes for the glucocorticoid receptor, which conveys glucocorticoid signals from the HPA axis. Women with PTSD also showed significant up-regulation of target genes for NF-κB and non-significant down-regulation of target genes for GR, but significant down-regulation of target genes for CREB-ATF. Altered transcriptional control of monocyte gene expression could contribute to exaggerated inflammatory activity in PTSD.





Autor: Aoife O’Donovan, Bing Sun, Steve Cole, Hans Rempel, Maryann Lenoci, Lynn Pulliam, and Thomas Neylan

Fuente: https://www.hindawi.com/



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