Are There Modifiable Risk Factors to Improve AKIReport as inadecuate

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BioMed Research International - Volume 2017 2017, Article ID 5605634, 9 pages -

Review ArticleDepartment of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, Beijing 100853, China

Correspondence should be addressed to Zhe Feng and Xiangmei Chen

Received 7 January 2017; Revised 26 April 2017; Accepted 23 May 2017; Published 4 July 2017

Academic Editor: Jean Claude Dussaule

Copyright © 2017 Sasa Nie et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Acute kidney injury AKI is a common critical syndrome, with high morbidity and mortality. Patients with AKI typically have an adverse prognosis, from incident chronic kidney disease CKD, progression to end-stage renal disease ESRD, subsequent cardiovascular disease, and ultimately death. However, there is currently no effective therapy for AKI. Early detection of risk factors for AKI may offer a good approach to prevention or early intervention. Traditional risk factors include extreme age, many common comorbid diseases, such as preexisting CKD, some specific exposures, such as sepsis, and exposure to some nephrotoxic agents. Recently, several novel risk factors for AKI, such as hyperuricemia, hypoalbuminemia, obesity, anemia, and hyperglycemia, have been identified. The underlying mechanisms between these nontraditional risk factors and AKI and whether their correction can reduce AKI occurrence remain to be clarified. This review describes the current epidemiology of AKI, summarizes its outcome, outlines the traditional risk profile, and finally highlights some recently identified novel risk factors.

Author: Sasa Nie, Li Tang, Weiguang Zhang, Zhe Feng, and Xiangmei Chen



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