Serum Levels of TNF-α, IL-12-23 p40, and IL-17 in Psoriatic Patients with and without Nail Psoriasis: A Cross-Sectional StudyReport as inadecuate

Serum Levels of TNF-α, IL-12-23 p40, and IL-17 in Psoriatic Patients with and without Nail Psoriasis: A Cross-Sectional Study - Download this document for free, or read online. Document in PDF available to download.

The Scientific World Journal - Volume 2014 2014, Article ID 508178, 5 pages -

Research Article

2nd Department of Dermatology and Venereology, Papageorgiou General Hospital, Aristotle University School of Medicine, Ring Road Thessalonikis, Nea Efkarpia, 56403 Thessaloniki, Greece

1st Department of Microbiology, Aristotle University School of Medicine, 54124 Thessaloniki, Greece

Received 17 March 2014; Accepted 18 December 2014; Published 31 December 2014

Academic Editor: Uwe Wollina

Copyright © 2014 Aikaterini Kyriakou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Nail involvement has started playing a major role in the overall assessment and management of psoriatic disease. Biologics indicated for moderate to severe chronic plaque psoriasis are shown to be beneficial in nail disease. This study aimed to assess and compare the serum levels of TNF-α, IL-12-23 p40, and IL-17 in psoriatic patients with and without nail involvement. 52 consecutively selected patients with chronic plaque psoriasis were included in this cross-sectional study. Patients were studied and analyzed after they had been divided into 2 groups regarding the presence n = 24 or not n = 28 of nail psoriasis. The mean serum levels of TNF-α were significantly higher in the group of psoriatic patients with nail lesions compared to those without t-test; 5.40 ± 1.17 versus 3.80 ± 1.63, P = 0.026. However, the median serum levels of both IL-12-23 p40 Mann-Whitney; 92.52 34.35–126.87 versus 150.68 35.18–185.86, P = 0.297 and IL-17 Mann-Whitney; 28.49 0.00–28.49 versus 8.59 0.00–8.59, P = 0.714 did not significantly differ between the 2 groups. These results confirm the important role of TNF-α in the pathogenesis of nail psoriasis and may suggest that anti-TNF agents could be more beneficial in psoriatic nail disease than agents targeting IL-12-23 p40 or IL-17 and its receptors.

Author: Aikaterini Kyriakou, Aikaterini Patsatsi, Timoleon-Achilleas Vyzantiadis, and Dimitrios Sotiriadis



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