The in vitro mechanisms of isoniazid and ethionamide resistance poorly reflect those in vivo in Mycobacterium tuberculosisReportar como inadecuado




The in vitro mechanisms of isoniazid and ethionamide resistance poorly reflect those in vivo in Mycobacterium tuberculosis - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

* Corresponding author 1 Service de Bactériologie-Hygiène Hospitalière CHU Pitié-Salpêtrière 2 CIMI - Centre d-Immunologie et de Maladies Infectieuses 3 Centre National de Référence des Mycobactéries et de la Résistance aux Antituberculeux CHU Pitié-Salpêtrière 4 IAME - Infection, Antimicrobiens, Modélisation, Evolution 5 Service de Bactériologie CHU Lariboisière

Abstract : To be active against Mycobacterium tuberculosis, isoniazid INH and ethionamide ETH need to be activated by the catalase-peroxidase KatG for INH and by the mono-oxygenase EthA regulated by EthR for ETH 1. ETH and INH both target the enzyme InhA involved in the cell wall biosynthesis 2. Clinical isolates resistant R to INH and ETH display a wide range of mutations altering KatG mutation S315T in 70% of INH-R isolates, EthA in 50% of ETH-R isolates and, InhA and the inhA promoter in 25% of INH-R and 65% of ETH-R isolates 1 and 3.





Autor: Florence Brossier - Emmanuelle Cambau - Emilie Tessier - Vincent Jarlier - Wladimir Sougakoff -

Fuente: https://hal.archives-ouvertes.fr/



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