An urn model of the development of L-M cone ratios in human and macaque retinas.Reportar como inadecuado




An urn model of the development of L-M cone ratios in human and macaque retinas. - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

* Corresponding author 1 Cerveau et vision 2 Department of Cell Biology, Neurobiology and Anatomy; Department of Ophthalmology

Abstract : A model of the development of L-M cone ratios in the Old World primate retina is presented. It is supposed that during gestation, the cone cycles randomly between states in which it transcribes either L or M opsin. The current state determines and increases the probability that it will transcribe the same opsin in future cycles. These assumptions are sufficient to formalize the process as a Markov chain that can be modeled as an urn containing two types of balls, L and M. Drawing one ball results in the increase of its species and the decrease of the other. Over the long run, the urn will become populated with a single type of ball. This state corresponds to the photoreceptor adopting a fixed identity for its lifetime. We investigate the effect of the number of states and the rule that regulates the advantage of transition toward one cone type or another on the relation between fetal and adult L-M cone ratios. In the range of 100 to 1000 states, small variations of the initial L-M ratio or the transition advantage can each generate large changes in the final L-M ratio, in qualitative accord with the variation seen in human adult retinas. The time course to attain stable L-M ratios also varies with these parameters. If it is believed that the cycling follows a circadian rhythm, then final L-M cone ratios would be expected to stabilize shortly after birth in the human being and the macaque.





Autor: Kenneth Knoblauch - Maureen Neitz - Jay Neitz -

Fuente: https://hal.archives-ouvertes.fr/



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