Long-term outcomes of occipital nerve stimulation for chronic migraine: a cohort of 53 patientsReportar como inadecuado




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The Journal of Headache and Pain

, 17:68

First Online: 30 July 2016Received: 17 May 2016Accepted: 22 July 2016

Abstract

BackgroundChronic migraine affects up to 2 % of the general population and has a substantial impact on sufferers. Occipital nerve stimulation has been investigated as a potentially effective treatment for refractory chronic migraine. Results from randomised controlled trials and open label studies have been inconclusive with little long-term data available.

MethodsThe long-term efficacy, functional outcome and safety of occipital nerve stimulation was evaluated in an uncontrolled, open-label, prospective study of 53 intractable chronic migraine patients.

ResultsFifty-three patients were implanted in a single centre between 2007 and 2013. Patients had a mean age of 47.75 years range 26–70, had suffered chronic migraine for around 12 years and had failed a mean of 9 range 4–19 preventative treatments prior to implant. Eighteen patients had other chronic headache phenotypes in addition to chronic migraine. After a median follow-up of 42.00 months range 6–97 monthly moderate-to-severe headache days i.e. days on which pain was more than 4 on the verbal rating score and lasted at least 4 h reduced by 8.51 days p < 0.001 in the whole cohort, 5.80 days p < 0.01 in those with chronic migraine alone and 12.16 days p < 0.001 in those with multiple phenotypes including chronic migraine. Response rate of the whole group defined as a >30 % reduction in monthly moderate-to-severe headache days was observed in 45.3 % of the whole cohort, 34.3 % of those with chronic migraine alone and 66.7 % in those with multiple headache types. Mean subjective patient estimate of improvement was 31.7 %. Significant reductions were also seen in outcome measures such as pain intensity 1.34 points, p < 0.001, all monthly headache days 5.66 days, p < 0.001 and pain duration 4.54 h, p < 0.001. Responders showed substantial reductions in headache-related disability, affect scores and quality of life measures. Adverse event rates were favourable with no episodes of lead migration and only one minor infection reported.

ConclusionsOccipital nerve stimulation may be a safe and efficacious treatment for highly intractable chronic migraine patients even after relatively prolonged follow up of a median of over 3 years.

KeywordsChronic migraine Headache Neurostimulation Occipital nerve stimulation Electronic supplementary materialThe online version of this article doi:10.1186-s10194-016-0659-0 contains supplementary material, which is available to authorized users.

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Autor: Sarah Miller - Laurence Watkins - Manjit Matharu

Fuente: https://link.springer.com/







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