Release of PACAP-38 in episodic cluster headache patients – an exploratory studyReportar como inadecuado




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The Journal of Headache and Pain

, 17:69

First Online: 30 July 2016Received: 22 May 2016Accepted: 22 July 2016

Abstract

BackgroundActivation of the trigeminal-autonomic reflex, involving the trigeminal ganglion, the superior salivatory nucleus and the sphenopalatine ganglion SPG is crucial in the pathophysiology of cluster headache CH. Since pituitary adenylate cyclase-activating polypeptide-38 PACAP-38 is present both in the SPG and the trigeminal ganglion TG and its role in migraine has been described, our aim was to determine the plasma PACAP-38 levels in different phases of episodic CH ECH.

Peripheral cubital fossa blood samples were taken during the ictal and inter-bout periods of male ECH patients and from age-matched healthy controls n = 9. Plasma PACAP-38-like immunoreactivity LI was measured with specific and sensitive radioimmunoassay.

FindingsSignificantly lower plasma PACAP-38-LI was detected in the inter-bout period of ECH patients than in healthy controls. However, PACAP-38 was significantly elevated in the plasma during CH attacks as compared to the inter-bout phase in the same subjects n = 5.

ConclusionsThis exploratory study suggests that PACAP-38 may be released during the attacks of ECH. Further patients and long-term follow-up are necessary to reveal its function.

KeywordsEpisodic cluster headache Plasma PACAP-38-LI Inter-bout period Ictal phase  Download fulltext PDF



Autor: Bernadett Tuka - Nikoletta Szabó - Eszter Tóth - Zsigmond Tamás Kincses - Árpád Párdutz - Délia Szok - Tamás Kört

Fuente: https://link.springer.com/







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