Economic Evaluation of Fluticasone Propionate-Formoterol Flutiform® vs. Fluticasone-Salmeterol and Budesonide-Formoterol in SpainReportar como inadecuado




Economic Evaluation of Fluticasone Propionate-Formoterol Flutiform® vs. Fluticasone-Salmeterol and Budesonide-Formoterol in Spain - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Pulmonary Therapy

, Volume 2, Issue 2, pp 199–213

First Online: 17 October 2016Received: 01 September 2016

Abstract

IntroductionThe aim of this economic evaluation was to estimate the cost-effectiveness of fluticasone propionate-formoterol FP-FORM; Flutiform and compare it to those of fluticasone-salmeterol FS and budesonide-formoterol BF when used in the treatment of adult patients with moderate-to-severe asthma.

MethodsA Markov model was developed with five asthma health states: successful control, suboptimal control, outpatient-managed exacerbation, inpatient-managed exacerbation, and death. The time horizon was set at 12 months. Transition probabilities and indirect resource utilization were derived from previous international and Spanish publications. Univariate and probabilistic sensitivity analyses SAs were applied.

ResultsFP-FORM was less expensive to acquire than FS or BF 20% lower than FS and 30% lower than BF, while the quality-adjusted life years QALYs of the three options compared were very similar. Cost per patient in the FP-FORM cohort was 9326€-year, making it the cheapest option, 1.5% cheaper than FS and 2.6% cheaper than BF. The suboptimal control health state dominated the costs 80% of the total cost in each of the analyzed options and scenarios. The results of the SAs verified the data obtained from the base case scenario.

ConclusionsFrom a Spanish societal perspective, in 2014, FP-FORM produced a similar gain in QALYs but at a lower cost when compared to FS and BF in a highly meaningful number of replications and scenarios. FP-FORM can therefore be considered a cost-effective option in the treatment of moderate-to-severe asthma in Spain. The cost savings were mainly due to the significantly lower acquisition cost of FP-FORM than the other two options.

FundingMundipharma Pharmaceuticals, S.L., Madrid, Spain.

KeywordsAsthma Economic Evaluation Propionate-formoterol Enhanced contentTo view enhanced content for this article go to http:-www.medengine.com-Redeem-A9E6F06074280500.

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Autor: Eva Martínez Moragón - Julio Delgado - Pedro Ojeda - Luis Pérez del Llano - Juan Manuel Collar - Cristina Antón-Rodr

Fuente: https://link.springer.com/article/10.1007/s41030-016-0021-3







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