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Case Reports in Hematology - Volume 2014 2014, Article ID 757625, 5 pages -

Case Report

Pediatric Hematology-Oncology Department, Goztepe Training Hospital, Istanbul Medeniyet University, 34724 Istanbul, Turkey

Pathology Department, Goztepe Training Hospital, Istanbul Medeniyet University, 34724 Istanbul, Turkey

Received 1 May 2014; Accepted 15 August 2014; Published 3 September 2014

Academic Editor: Panayiotis Tsirigotis

Copyright © 2014 Aylin Canbolat Ayhan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Myeloid sarcoma is an extramedullary neoplasm of immature myeloid cells. Our study reports a presentation of myeloid sarcoma which presented with severe leukemoid reaction as a secondary malignancy in a patient who was treated for acute lymphoblastic leukemia previously. The case emphasizes the difficulties in diagnosis of patients who do not have concomitant leukemia. Case Presentation. A 6-year-old girl who was treated for acute lymphoblastic leukemia previously presented with fatigue, paleness, and hepatosplenomegaly. Peripheral blood smear and bone marrow aspirate examination did not demonstrate any blasts in spite of severe leukemoid reaction with a white cell count 158000-mm

. FDG-PET CT revealed slight uptake in cervical and supraclavicular lymph nodes. Excisional lymph node biopsy was performed from these lymph nodes and it showed myeloid sarcoma. Conclusion. Myeloid sarcoma can develop as a secondary malignancy in children who are treated for acute lymphoblastic leukemia. It can be associated with severe leukemoid reaction and diagnosis may be difficult if there is not concomitant leukemia. PET-CT is helpful in such cases.





Autor: Aylin Canbolat Ayhan, Cetin Timur, Seyma Sonmez, Ebru Zemheri, and Asım Yoruk

Fuente: https://www.hindawi.com/



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