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RETRACTED This article has been retracted, upon the authors’ request, as it is essentially identical in content with a previously published paper by the same authors titled “Bacteria and Obesity: The Proportion Makes the Difference,” published in Surgery: Current Research 2013 3:152.

ISRN ObesityVolume 2014 2014, Article ID 651895, 8 pages

Review Article

Department of Surgery, Medical School, Aristotle University of Thessaloniki, Thessaloniki 54006, Greece

Fourth Department of Internal Medicine, University of Athens Medical School, Athens 12462, Greece

Received 4 January 2014; Accepted 6 February 2014; Published 6 March 2014

Academic Editors: D. Micic and E. K. Naderali

Copyright © 2014 Katerina Kotzampassi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Obesity is a major public health concern, caused by a combination of increased consumption of energy-dense foods and reduced physical activity, with contributions from host genetics, environment, and adipose tissue inflammation. In recent years, the gut microbiome has also been found to be implicated and augmented research in mice and humans have attributed to it both the manifestation and-or exacerbation of this major epidemic and vice versa. At the experimental level, analysis of fecal samples revealed a potential link between obesity and alterations in the gut flora drop in Bacteroidetes and increase in Firmicutes, the specific gut microbiome being associated with the obese phenotype. Conventionally raised mice were found to have over 40% more total body fat compared with those raised under germ-free conditions, while conventionalization of germ-free mice resulted in a significant increase in total body fat. Similarly, the sparse data in humans supports the fact that fat storage is favoured by the presence of the gut microbiota, through a multifaceted mechanism. Efforts to identify new therapeutic strategies to modulate gut microbiota would be of high priority for public health, and to date, probiotics and-or prebiotics seem to be the most effective tools.

Autor: Katerina Kotzampassi, Evangelos J. Giamarellos-Bourboulis, and George Stavrou

Fuente: https://www.hindawi.com/


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