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BioMed Research International - Volume 2016 2016, Article ID 6504593, 12 pages -

Review Article

Laboratory of Tissue Engineering-Innovative Technology Platforms for Tissue Engineering PON01 01059, Rizzoli Orthopedic Institute, 90100 Palermo, Italy

Department of Experimental and Clinical Medicine, Magna Graecia University and Medical Oncology Unit, Salvatore Venuta University Campus, 88100 Catanzaro, Italy

Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopedic Institute, 40136 Bologna, Italy

Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA

Received 25 September 2015; Accepted 1 December 2015

Academic Editor: Gang Liu

Copyright © 2016 Lavinia Raimondi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Multiple myeloma MM is a hematologic malignancy of differentiated plasma cells that accumulate in the bone marrow, where a complex microenvironment made by different cell types supports proliferation, survival, and drug resistance of tumor cells. MicroRNAs miRNAs are short non-coding RNAs that regulate gene expression at posttranscriptional level. Emerging evidence indicates that miRNAs are aberrantly expressed or functionally deregulated in MM cells as the result of multiple genetic or epigenetic mechanisms and that also the tumor microenvironment regulates MM cell functions by miRNAs. Consistently, modulation of miRNA levels in MM cells has been demonstrated to impair their functional interaction with the bone marrow microenvironment and to produce significant antitumor activity even able to overcome the protective bone marrow milieu. This review will describe the most recent findings on miRNA function in the context of MM bone marrow microenvironment, focusing on the therapeutic potential of miRNA-based approaches.





Autor: Lavinia Raimondi, Angela De Luca, Eugenio Morelli, Gianluca Giavaresi, Pierosandro Tagliaferri, Pierfrancesco Tassone, and N

Fuente: https://www.hindawi.com/



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