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The Scientific World Journal - Volume 2014 2014, Article ID 650393, 7 pages -

Research Article

Division of Nephrology, Department of Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan

Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, Kaohsiung 80708, Taiwan

Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan

Asia-Pacific Biotech Developing, Inc., Kaohsiung 80681, Taiwan

Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 90741, Taiwan

Department of Physiology, College of Medicine, National Cheng Kung University, 1 University Road, Tainan 70101, Taiwan

Department and Graduate Institute of Aquaculture, National Kaohsiung Marine University, Kaohsiung 81157, Taiwan

Center for Molecular Medicine, China Medical University Hospital, Taichung 40477, Taiwan

Graduate Institute of Cancer Biology, China Medical University, Cancer Center Building 8F, No. 6 Hsueh-Shih Road, Taichung 40477, Taiwan

Received 18 March 2014; Revised 4 June 2014; Accepted 16 June 2014; Published 10 July 2014

Academic Editor: George Panagiotis Chrousos

Copyright © 2014 Ming-Kai Tsai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Diabetes is a serious global health problem. Large-scale genome-wide association studies identified loci for type 2 diabetes mellitus T2DM, including adiponectin ADIPOQ gene and transcription factor 7-like 2 TCF7L2, but few studies clarified the effect of genetic polymorphisms of ADIPOQ and TCF7L2 on risk of T2DM. We attempted to elucidate association between T2DM and polymorphic variations of both in Taiwan’s Chinese Han population, with our retrospective case-control study genotyping single nucleotide polymorphisms SNPs in ADIPOQ and TCF7L2 genes both in 149 T2DM patients and in 139 healthy controls from Taiwan. Statistical analysis gauged association of these polymorphisms with risk of T2DM to show ADIPOQ rs1501299 polymorphism variations strongly correlated with T2DM risk , with rs2241766 polymorphism being not associated with T2DM . However, both polymorphisms rs7903146 and rs12255372 of TCF7L2 were rarely detected in Taiwanese people. This study avers that ADIPOQ rs1501299 polymorphism contributes to risk of T2DM in the Taiwanese population.





Autor: Ming-Kai Tsai, Hui-Min David Wang, Jeng-Chuan Shiang, I-Hung Chen, Chih-Chiang Wang, Ya-Fen Shiao, Wen-Sheng Liu, Tai-Jung

Fuente: https://www.hindawi.com/



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